产品展厅
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ALPL
- 品牌：湖南瑞威尔
- 货号：RWE20230505
- 发布日期： 2024-04-28
- 更新日期： 2024-08-29
产品详请
| 产地 | |
| 货号 | RWE20230505 |
| 品牌 | 湖南瑞威尔 |
| 用途 | 外贸出口、科学研究和化学试剂等领域 |
| 英文名称 | |
| 包装规格 | |
| CAS编号 | |
| 别名 | |
| 纯度 | % |
| 包装 | |
| 分子式 | |
| 级别 | 医药级 |
| There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. |
| References |
|---|
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J Rheumatol. 2009 Dec;36(12):2758-65. Calcif Tissue Int. 2009 Sep;85(3):228-34. |
| Specification | |
|---|---|
| Aliases | HOPS; TNAP; APTNAP; TNSALP; AP-TNAP |
| Entrez GeneID | 249 |
| Swissprot | P05186 |
| clone | 2F4 |
| WB Predicted band size | 57.3kDa |
| Host/Isotype | Mouse IgG1 |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen |
Purified recombinant fragment of human ALPL expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
