产品展厅
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DCX
- 品牌：湖南瑞威尔
- 货号：RWE20230258
- 发布日期： 2024-04-28
- 更新日期： 2024-08-29
产品详请
| 产地 | |
| 货号 | RWE20230258 |
| 品牌 | 湖南瑞威尔 |
| 用途 | 外贸出口、科学研究和化学试剂等领域 |
| 英文名称 | |
| 包装规格 | |
| CAS编号 | |
| 别名 | |
| 纯度 | % |
| 包装 | |
| 分子式 | |
| 级别 | 医药级 |
| This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. |
| References |
|---|
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1.FASEB J. 2009 Dec;23(12):4276-87. 2.J Cell Biol. 2010 Nov 1;191(3):463-70. |
| Specification | |
|---|---|
| Aliases | DC; DBCN; LISX; SCLH; XLIS |
| Entrez GeneID | 1641 |
| Swissprot | O43602 |
| clone | 2G5 |
| WB Predicted band size | 49.3kDa |
| Host/Isotype | Mouse IgG1 |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen |
Purified recombinant fragment of human DCX (AA: 362-411) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
