产品展厅
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ACVR1
- 品牌：湖南瑞威尔
- 货号：RWE20230205
- 发布日期： 2024-04-28
- 更新日期： 2024-08-29
产品详请
| 产地 | |
| 货号 | RWE20230205 |
| 品牌 | 湖南瑞威尔 |
| 用途 | 外贸出口、科学研究和化学试剂等领域 |
| 英文名称 | |
| 包装规格 | |
| CAS编号 | |
| 别名 | |
| 纯度 | % |
| 包装 | |
| 分子式 | |
| 级别 | 医药级 |
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Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. |
| References |
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1.Indian J Pediatr. 2014 Jun;81(6):617-9. 2.Nat Genet. 2014 May;46(5):457-61. |
| Specification | |
|---|---|
| Aliases | FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2 |
| Entrez GeneID | 90 |
| Swissprot | Q04771 |
| clone | 2E2C11 |
| WB Predicted band size | 57.2kDa |
| Host/Isotype | Mouse IgG1 |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ACVR1 (AA: 21-120) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
